8 Dangerous Drug Combinations You Shouldn't Mix

Save or bookmark this page: These are the over-the-counter remedies that are unsafe to use with prescription medications

dangerous drug combos

If you're taking: Prescription painkillers that contain acetaminophen (such as Tylox and Vicodin)
Don't take: Acetaminophen
The danger: Doubling up on acetaminophen could put you at risk for liver damage.

If you're taking: Antidepressants called monoamine oxidase inhibitors (such as Nardil and Parnate)
Don't take: Decongestants containing pseudoephedrine
The danger: The combination can cause a potentially deadly increase in blood pressure.

If you're taking: Diabetes medications (such as chlorpropamide)
Don't take: Aspirin
The danger: Aspirin makes diabetes meds less effective; light-headedness and fainting are possible.

If you're taking: Sedatives, muscle relaxants or antianxiety drugs (such as Ativan and Xanax)
Don't take: Antihistamines
The danger: Antihistamines increase the prescription drug's depressant, sleep-inducing effects.

If you're taking: Antibiotics
Don't take: Antacids
The danger: Ingredients in antacids bind to antibiotics, preventing the body from absorbing the antibiotic properly, thereby making the antibiotic ineffective.

If you're taking: Blood thinners (such as Coumadin)
Don't take: NSAIDs (such as aspirin, ibuprofen and naproxen)
The danger: The pain relievers intensify blood thinners' effects—which increases the risk of internal bleeding. That could lead to death.

If you're taking: Sedatives or tranquilizers (such as Valium and Xanax)
Don't take: Cough syrups with antihistamines or dextromethorphan
The danger: The combo could increase sedative effects, causing intense drowsiness.

If you're taking: High blood pressure drugs (such as Prinivil and Vasotec)
Don't take: Decongestants
The danger: The blood-pressure-lowering effects can be lost.